# Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed)

Source: https://welltoldgrants.com/grants/rfa-da-25-053-harnessing-artificial-intelligence-and-polypharmacology-to/  
Official notice: https://www.grants.gov/search-results-detail/352047

> National Institutes of Health offered grants of up to $400,000 to small businesses. Applications closed on July 25, 2024.

| Field | Value |
|---|---|
| Opportunity number | RFA-DA-25-053 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | July 25, 2024 |
| Award ceiling | $400,000 |
| Award floor | not stated |
| Expected awards | not stated |
| Total funding | not stated |
| Cost sharing | not required |
| Assistance Listings | 93.279 |

## Who can apply

- Small businesses

Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed

## What the grant funds

The purpose of this funding opportunity is to develop artificial intelligence tools and experimental assays to identify new pharmacotherapeutics with lower toxicity and higher efficacy for substance use disorders (SUD) Areas of interest include but are not limited to: 1) Development of AI tools to identify potential target combinations, design new molecules, conduct virtual preclinical studies to predict efficacy and toxicity, and model in vitro and in vivo polypharmacology 2) Development of assays to assess the effects of compounds on multiple targets or functions

## Questions people ask

### Is RFA-DA-25-053 still open?

No. It closed on July 25, 2024.

### Who can apply for Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed)?

National Institutes of Health accepted applications from small businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Harnessing Artificial Intelligence and Polypharmacology to Discover Pharmacotherapeutics for Substance Use Disorders (R41/R42 Clinical Trials Not Allowed)?

Closed July 25, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

Awards of up to $400,000 each.

### Who has been funded under RFA-DA-25-053?

NIH RePORTER lists 2 projects funded under RFA-DA-25-053 in fiscal 2025, at 2 institutions. The most were at Callentis Consulting Group LLC, Dark Matter Therapeutics, Inc.

### Who has won Drug Use and Addiction Research Programs grants before?

The largest recipients over five fiscal years were Yale Univ, The Johns Hopkins University, University of California, San Diego. The program made 5,071 awards worth $7.3 billion in that time.