Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)

Open Closes May 28, 2027 (209 days left) Opportunity RFA-AI-28-031

National Institutes of Health is offering grants of up to $3.5 million to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expects to make $33.0 million in total. Applications close on May 28, 2027.

From the official notice on Grants.gov, last changed October 2, 2026. Checked October 31, 2026.

Key dates

PostedOctober 2, 2026
DeadlineMay 28, 2027
Archived by Grants.govJuly 28, 2027

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Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards. Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

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Is this a realistic fit?

What the grant funds

The purpose of this notice of funding opportunity (NOFO) is to support multidisciplinary consortia of structural biologists, microbiologists, and associated experts to solve complex biological structures related to the prevention, treatment, and cure of HIV and other infectious diseases. Centers are expected to facilitate new collaborations, leverage shared resources, offer services and resources to the research community, and train the next generation of scientists engaged in structural biology of infectious diseases.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to National Institutes of Health, BSPDAIDSNOFO@mail.nih.gov, 301-402-2541.

Open the official notice

Questions people ask

Who can apply for Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)?

Closes May 28, 2027 (209 days left). Confirm the date and time in the official notice on Grants.gov.

How much funding is available?

Awards of up to $3.5 million each. About $33.0 million in total.

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