# Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)

Source: https://welltoldgrants.com/grants/rfa-ai-28-012-translational-centers-using-microphysiological-systems-for/  
Official notice: https://www.grants.gov/search-results-detail/362954

> National Institutes of Health is offering grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expects to make about 5 awards worth $7.0 million in total. Applications close on January 29, 2027.

| Field | Value |
|---|---|
| Opportunity number | RFA-AI-28-012 |
| Agency | National Institutes of Health |
| Status | Open |
| Deadline | January 29, 2027 |
| Award ceiling | not stated |
| Award floor | not stated |
| Expected awards | 5 |
| Total funding | $7.0 million |
| Cost sharing | not required |
| Assistance Listings | 93.310, 93.855 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

## What the grant funds

The purpose of this notice of funding opportunity (NOFO) is to support a consortium of Translational Centers using Microphysiological Systems (MPS) for Infectious Diseases (TCMID). Recent efforts in the MPS fields are moving towards validation and regulatory use but have not focused upon models studying infectious diseases and testing of medical interventions. The NIH and FDA have recently issued guidance and established initiatives for enhancing use of New Approach Methodologies (NAMs) in research and product development. This includes in vitro systems that allow scientists to model human disease and capture human variability and patient-specific characteristics that will accelerate safer treatments for patients while reducing costs and sparing use of laboratory animals. To meet this need, the Centers will refine well validated human tissue models studying infectious diseases to a level consistent with regulatory qualifications that will promote their adoption for use by product developers, supporting regulatory acceptance.

## Questions people ask

### Who can apply for Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)?

Closes January 29, 2027 (90 days left). Confirm the date and time in the official notice on Grants.gov.

### How much funding is available?

About $7.0 million in total across about 5 awards.