Well Told Grants

Grants / Department of Health and Human Services / National Institutes of Health

HIV/AIDS Clinical Trials Network Leadership and Operations Centers

Forecast Expected deadline January 22, 2027 Opportunity RFA-AI-28-001

National Institutes of Health plans to offer grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It is a forecast: the notice is expected around August 25, 2026, with applications due around January 22, 2027.

From the official notice on Grants.gov, last changed April 8, 2026. Checked October 31, 2026.

Key dates

Forecast postedApril 8, 2026
Expected postingAugust 25, 2026
Expected deadlineJanuary 22, 2027
Expected award dateDecember 1, 2027

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Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations.

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Is this a realistic fit?

What the grant funds

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance the National Institutes of Health (NIH) mission by supporting four Clinical Trials Networks (CTNs) each comprised of a Leadership and Operations Center (LOC), Statistical and Data Management Center, and Laboratory Center working with Clinical Trials Units to advance prevention, treatment, and implementation research designed to end the HIV epidemic. This NOFO will solicit applications for four LOCs to provide scientific leadership, research prioritization, and conduct studies in a CTN. A LOC develops the research agenda in one of these areas: 1) HIV therapeutics/cure, and prevention/treatment for HIV-associated comorbidities in adults; 2) HIV prevention/treatment in maternal/adolescent/pediatric populations; 3) biomedical HIV prevention strategies for adults/adolescents; and 4) immune-based prevention for HIV and HIV-associated diseases. CTNs will conduct HIV implementation research improving uptake of evidence-based prevention and treatment strategies across the lifespan. High impact LOC studies will produce crucial findings significantly benefiting Americans with or at-risk of HIV and HIV-associated diseases. Grant authorities that allow NIAID to forecast this opportunity are: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to Division of AIDS, sciops@niaid.nih.gov, Please contact via e-mail..

Open the official notice

Questions people ask

Who can apply for HIV/AIDS Clinical Trials Network Leadership and Operations Centers?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for HIV/AIDS Clinical Trials Network Leadership and Operations Centers?

Expected deadline January 22, 2027. Confirm the date and time in the official notice on Grants.gov.

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