# Fc-Dependent Mechanisms of Antibody-Mediated Killing (R01 Clinical Trial Not Allowed)

Source: https://welltoldgrants.com/grants/rfa-ai-23-054-fc-dependent-mechanisms-of-antibody-mediated-killing-r01/  
Official notice: https://www.grants.gov/search-results-detail/350342

> National Institutes of Health offered grants of up to $300,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on January 26, 2024.

| Field | Value |
|---|---|
| Opportunity number | RFA-AI-23-054 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | January 26, 2024 |
| Award ceiling | $300,000 |
| Award floor | not stated |
| Expected awards | not stated |
| Total funding | not stated |
| Cost sharing | not required |
| Assistance Listings | 93.855 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

## What the grant funds

The purpose of this notice of funding opportunity (NOFO) is to support basic research that will elucidate mechanisms of Fc-mediated antibody functions, including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). Supported studies are expected to generate foundational data and tools that can be applied to the prediction of Fc-mediated killing activity by antibodies. Such data should accelerate development of therapeutic monoclonal antibodies and design of vaccines or vaccine-adjuvant combinations that induce antibody responses capable of killing infected host cells, particularly in cases where induction of neutralizing antibodies fails or is insufficient for clearance of infection

## Questions people ask

### Is RFA-AI-23-054 still open?

No. It closed on January 26, 2024.

### Who can apply for Fc-Dependent Mechanisms of Antibody-Mediated Killing (R01 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Fc-Dependent Mechanisms of Antibody-Mediated Killing (R01 Clinical Trial Not Allowed)?

Closed January 26, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

Awards of up to $300,000 each.

### Who has been funded under RFA-AI-23-054?

NIH RePORTER lists 6 projects funded under RFA-AI-23-054 in fiscal 2025 to 2026, at 6 institutions. The most were at University of Maryland Baltimore, North Carolina State University Raleigh, University of Georgia.

### Who has won Allergy and Infectious Diseases Research grants before?

The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.