# Genetic Tools for Understanding Rickettsial and Related Infections (R61/R33 Clinical Trial Not Allowed)

Source: https://welltoldgrants.com/grants/rfa-ai-22-047-genetic-tools-for-understanding-rickettsial-and-related/  
Official notice: https://www.grants.gov/search-results-detail/343899

> National Institutes of Health offered grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on February 14, 2023.

| Field | Value |
|---|---|
| Opportunity number | RFA-AI-22-047 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | February 14, 2023 |
| Award ceiling | not stated |
| Award floor | not stated |
| Expected awards | not stated |
| Total funding | not stated |
| Cost sharing | not required |
| Assistance Listings | 93.855 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

## What the grant funds

A comprehensive understanding of pathogenic bacteriology requires the ability to generate and study genetically altered bacterial strains. For the obligate intracellular human pathogens of the order Rickettsialesincluding Anaplasma, Ehrilichia, Orientia and Rickettsia speciesthese tools have long lagged behind those available for extracellular bacteria. While recent advances have demonstrated the feasibility of genetically manipulating these bacteria, inherent limitations associated with their obligate intracellular nature and reduced genomes have hindered large-scale generation of useful mutants across all species. This funding opportunity will address that research gap by dedicating support to the generation and functional characterization of mutant libraries for rickettsial species that cause infections in humans, and to the application of these new tools to better understanding the biology of rickettsial pathogens.

## Questions people ask

### Is RFA-AI-22-047 still open?

No. It closed on February 14, 2023.

### Who can apply for Genetic Tools for Understanding Rickettsial and Related Infections (R61/R33 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Genetic Tools for Understanding Rickettsial and Related Infections (R61/R33 Clinical Trial Not Allowed)?

Closed February 14, 2023. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### Who has been funded under RFA-AI-22-047?

NIH RePORTER lists 7 projects funded under RFA-AI-22-047 in fiscal 2024 to 2026, at 7 institutions. The most were at Virginia Commonwealth University, Johns Hopkins University, Washington State University.

### Who has won Allergy and Infectious Diseases Research grants before?

The largest recipients over five fiscal years were Fred Hutchinson Cancer Center, Duke University, University of California, Los Angeles. The program made 13,282 awards worth $22 billion in that time.