# Understanding the mechanisms underlying the age-related changes in gait biomechanics and the impact on the increased metabolic cost of walking (R01 Clinical Trial Optional)

Source: https://welltoldgrants.com/grants/rfa-ag-25-030-understanding-the-mechanisms-underlying-the-age-related/  
Official notice: https://www.grants.gov/search-results-detail/356215

> National Institutes of Health offered grants of up to $500,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications closed on November 7, 2024.

| Field | Value |
|---|---|
| Opportunity number | RFA-AG-25-030 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | November 7, 2024 |
| Award ceiling | $500,000 |
| Award floor | not stated |
| Expected awards | not stated |
| Total funding | not stated |
| Cost sharing | not required |
| Assistance Listings | 93.866 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

## What the grant funds

The National Institute on Aging (NIA)invitesR01applicationsthat proposehuman studiesto better understand the mechanisms underlying compensatory gait, posture and molecular changes that contribute to slower walking speed and increased metabolic cost of walking. This Notice of Funding Opportunity (NOFO) encourages interdisciplinary collaborations to design integrative approaches that explore interactions among multiple systems (e.g., skeletal, muscle, tendon, somatosensory and central nervous). This NOFO also encourages innovative approaches such as computational modeling, imaging and sensor technologies, machine learning and artificial intelligence to disentangle compensatory gait alterations with aging that contribute to increased metabolic cost of walking and fatigue. Areas of interest include: 1) mechanisms and effects of central nervous system changes; 2) neuromuscular changes; 3) skeletal muscle bioenergetics 4) computational modeling and simulation; and5) changes in tissue structure and function (e.g., muscle-tendon complex, extracellular matrix).

## Questions people ask

### Is RFA-AG-25-030 still open?

No. It closed on November 7, 2024.

### Who can apply for Understanding the mechanisms underlying the age-related changes in gait biomechanics and the impact on the increased metabolic cost of walking (R01 Clinical Trial Optional)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Understanding the mechanisms underlying the age-related changes in gait biomechanics and the impact on the increased metabolic cost of walking (R01 Clinical Trial Optional)?

Closed November 7, 2024. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

Awards of up to $500,000 each.

### Who has been funded under RFA-AG-25-030?

NIH RePORTER lists 3 projects funded under RFA-AG-25-030 in fiscal 2025 to 2026, at 3 institutions. The most were at Johns Hopkins University, University of Massachusetts Amherst, Georgia Institute of Technology.

### Who has won Aging Research grants before?

The largest recipients over five fiscal years were The Regents of the University of California, San Francisco, The Trustees of Columbia University in the City of New York, University of Southern California. The program made 11,026 awards worth $19 billion in that time.