# Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)

Source: https://welltoldgrants.com/grants/par-29-002-development-of-models-new-approach-methodologies-and/  
Official notice: https://www.grants.gov/search-results-detail/363877

> National Institutes of Health plans to offer grants of up to $500,000 (at least $190,000) to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expects to make about 15 awards. It is a forecast: the notice is expected around December 16, 2027, with applications due around February 16, 2028.

| Field | Value |
|---|---|
| Opportunity number | PAR-29-002 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | expected February 16, 2028 |
| Award ceiling | $500,000 |
| Award floor | $190,000 |
| Expected awards | 15 |
| Total funding | not stated |
| Cost sharing | not required |
| Assistance Listings | 93.351 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

## What the grant funds

This notice of funding opportunity (NOFO) encourages innovative research to develop, characterize, improve or preserve research models and model related biological materials, and to develop or improve technologies, including new approach methodologies (NAMs), for studies relevant to human health and diseases. This NOFO also seeks projects aimed at improving the identification and control of factors that could confound or interfere with the use of research models in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include research model(s) or NAM(s) and must explore multiple body systems or multiple categories of diseases affecting multiple body systems. Applications that develop models focused on a specific disease, a narrow area of research, or a single body system, or propose studies primarily relevant to a single NIH IC will be considered not acceptable to this NOFO.

## Questions people ask

### Who can apply for Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)?

Expected deadline February 16, 2028. Confirm the date and time in the official notice on Grants.gov.

### How much funding is available?

Awards of up to $500,000 each.