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Grants / Department of Health and Human Services / National Institutes of Health

INCLUDE Project: Omics Phenotypes Related to Down Syndrome (X01 Clinical Trial Not Allowed)

Forecast Expected deadline June 15, 2027 Opportunity PAR-27-117

National Institutes of Health plans to offer grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It is a forecast: the notice is expected around April 15, 2027, with applications due around June 15, 2027.

From the official notice on Grants.gov, last changed July 28, 2026. Checked October 31, 2026.

Key dates

Forecast postedJuly 28, 2026
Expected postingApril 15, 2027
Expected deadlineJune 15, 2027
Expected award dateApril 1, 2028

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Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

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What the grant funds

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to submit samples to NIH INCLUDE Project-supported resources to generate a large volume of integrated genomic and multi-omics data that will facilitate discovery of the molecular mechanisms of health conditions related to Down syndrome. The resulting data, and associated clinical and phenotypic data, will become part of the INCLUDE Data Hub for sharing with the research community. No funding will be provided directly to applicants under this NOFO. Applicants are encouraged to propose omics assays of existing biospecimens collected from individuals with Down syndrome and controls.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to The INCLUDE Project, DownSyndromeINCLUDE@mail.nih.gov, Please contact via e-mail..

Open the official notice

Questions people ask

Who can apply for INCLUDE Project: Omics Phenotypes Related to Down Syndrome (X01 Clinical Trial Not Allowed)?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for INCLUDE Project: Omics Phenotypes Related to Down Syndrome (X01 Clinical Trial Not Allowed)?

Expected deadline June 15, 2027. Confirm the date and time in the official notice on Grants.gov.

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