Grants / Department of Health and Human Services / National Institutes of Health

Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)

Forecast Expected deadline January 5, 2027 Opportunity PAR-27-040

• Award ceilingnot stated
• Award floornot stated
• Expected awardsnot stated
• Total fundingnot stated
• Cost sharingNot required
• Funding typeGrant

Key dates

Add the deadline to your calendar

Who can apply

This opportunity is open to small businesses.

• Small businesses

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.

More grants for small businesses.

Is this a realistic fit?

• No cost sharing or match is required.

What the grant funds

The National Institutes of Health (NIH), including the participating Institutes, Centers and Offices, intends to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I, and Fast-Track grant applications for the Small Business Transition Grant. Through this NOFO, NIH will support early-career scientists transitioning to entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects, including identification of complementary industry mentors and career development resources. This NOFO will utilize the R41/R42 activity code. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. This opportunity is available to first-time Principal Investigators, and key personnel must include a mentor with measurable effort committed to the project.

Category: Health.

How to apply

1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to NIH SEED (Small business Education and Entrepreneurial Development), Office of Extramural Research (OER), SEEDinfo@nih.gov, 301-827-8595.

Open the official notice