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Grants / Department of Health and Human Services / National Institutes of Health

Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI)

Open Closes February 6, 2029 (829 days left) Opportunity PAR-27-032

National Institutes of Health is offering grants to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. Applications close on February 6, 2029.

From the official notice on Grants.gov, last changed May 12, 2026. Checked October 31, 2026.

Key dates

PostedMay 12, 2026
DeadlineFebruary 6, 2029
Archived by Grants.govApril 7, 2029

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Who can apply

This opportunity is open to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses.

Refer to the Eligibility section in the NOFO for additional information on eligibility. Foreign institutions: Foreign components, as defined in the NIH Grants Policy Statement, are allowed. These types of organizations are not eligible to apply: Non-domestic (non-U.S.) entities (foreign institutions), Non-domestic (non-U.S.) components of U.S. organizations.

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Is this a realistic fit?

What the grant funds

The Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators (ESIs) provides support for ESIs with a program of research that aligns with the NIGMS mission.MIRA distributes funding among promising investigators across the country. The goal is to boost scientific productivity and the chances for important breakthroughs. Through this program, investigators can:Receive independent research funding early to start and sustain strong research careers. Explore new, unique research areas in the NIGMS mission. Take on ambitious, creative projects. Shift focus to include emerging techniques and technologies as needed. Devote more time to mentoring trainees in a stable research environment.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to National Institutes of Health, NIGMS-ESIMIRA@nigms.nih.gov, 301-402-2541.

Open the official notice

Questions people ask

Who can apply for Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI)?

National Institutes of Health accepts applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

What is the deadline for Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators (ESI)?

Closes February 6, 2029 (829 days left). Confirm the date and time in the official notice on Grants.gov.

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