# Role of Defective Proviruses in HIV Persistence (R01 Clinical Trial Not Allowed)

Source: https://welltoldgrants.com/grants/par-25-330-role-of-defective-proviruses-in-hiv-persistence-r01/  
Official notice: https://www.grants.gov/search-results-detail/357590

> National Institutes of Health offered grants of up to $500,000 to nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. It expected to make $500,000 in total. Applications closed on February 19, 2026.

| Field | Value |
|---|---|
| Opportunity number | PAR-25-330 |
| Agency | National Institutes of Health |
| Status | Forecast |
| Deadline | February 19, 2026 |
| Award ceiling | $500,000 |
| Award floor | not stated |
| Expected awards | not stated |
| Total funding | $500,000 |
| Cost sharing | not required |
| Assistance Listings | 93.242, 93.847, 93.855, 93.865 |

## Who can apply

- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

## What the grant funds

The purpose of this notice of funding opportunity (NOFO) is to support research to define the impact of defective HIV proviruses on mechanisms of HIV persistence and pathogenesis during antiretroviral treatment and their potential deleterious effects on HIV cure strategies and interference with HIV-specific molecular assays.

## Questions people ask

### Is PAR-25-330 still open?

No. It closed on February 19, 2026.

### Who can apply for Role of Defective Proviruses in HIV Persistence (R01 Clinical Trial Not Allowed)?

National Institutes of Health accepted applications from nonprofits, colleges and universities, state and local governments, tribes, small businesses and businesses. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Role of Defective Proviruses in HIV Persistence (R01 Clinical Trial Not Allowed)?

Closed February 19, 2026. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

Awards of up to $500,000 each. About $500,000 in total.

### Who has been funded under PAR-25-330?

NIH RePORTER lists 4 projects funded under PAR-25-330 in fiscal 2026, at 3 institutions. The most were at Johns Hopkins University, University of Texas Med BR Galveston, Sante Quebec Centre Hospitalier de L'Universite de Montreal.

### Who has won Mental Health Research Grants grants before?

The largest recipients over five fiscal years were Yale Univ, University of Pittsburgh - of the Commonwealth System of Higher Education, University of California, Los Angeles. The program made 6,785 awards worth $8.8 billion in that time.