# DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award

Source: https://welltoldgrants.com/grants/ht942525alsrppcta-dod-amyotrophic-lateral-sclerosis-pilot-clinical-trial-award/  
Official notice: https://www.grants.gov/search-results-detail/358723

> Defense Health Agency Contracting Activity - DHACA offered grants to any type of organization. It expected to make about 2 awards worth $5.6 million in total. Applications closed on August 27, 2025.

| Field | Value |
|---|---|
| Opportunity number | HT942525ALSRPPCTA |
| Agency | Defense Health Agency Contracting Activity - DHACA |
| Status | Forecast |
| Deadline | August 27, 2025 |
| Award ceiling | not stated |
| Award floor | not stated |
| Expected awards | 2 |
| Total funding | $5.6 million |
| Cost sharing | not required |
| Assistance Listings | 12.420 |

## Who can apply

- Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"

## What the grant funds

Summary: The fiscal year 2025 (FY25) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of Amyotrophic Lateral Sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials. Applications must address one of the following focus areas: Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway. Clinical Care: Improving aspects of clinical care and symptom management for ALS. Distinctive Features: Funding from this award mechanism must support a clinical trial. Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design. All applications are required to incorporate a Community Collaboration Plan, as described in Attachment 8 to optimize research impact. The clinical trial should begin no later than 12 months after the award date or 18 months for FDA-regulated studies.

## Questions people ask

### Is HT942525ALSRPPCTA still open?

No. It closed on August 27, 2025. A newer notice is open: HT942526BCRPCREA2, closes November 18, 2026 (11 days left).

### Who can apply for DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award?

Defense Health Agency Contracting Activity - DHACA accepted applications from any type of organization.

### What is the deadline for DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award?

Closed August 27, 2025. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

About $5.6 million in total across about 2 awards.

### Who has won Military Medical Research and Development grants before?

The largest recipients over five fiscal years were The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The Univeristy of Texas M.D. Anderson Cancer Center, The Johns Hopkins University. The program made 5,470 awards worth $6.9 billion in that time.