# Genomics-Enabled Plant Biology for Determination of Gene Function

Source: https://welltoldgrants.com/grants/de-foa-0002601-genomics-enabled-plant-biology-for-determination-of-gene/  
Official notice: https://www.grants.gov/search-results-detail/336990

> Office of Science offered grants of up to $1.0 million (at least $250,000) to the applicants described in the notice. It expected to make $30.0 million in total. Applications closed on March 25, 2022.

| Field | Value |
|---|---|
| Opportunity number | DE-FOA-0002601 |
| Agency | Office of Science |
| Status | Forecast |
| Deadline | March 25, 2022 |
| Award ceiling | $1.0 million |
| Award floor | $250,000 |
| Expected awards | not stated |
| Total funding | $30.0 million |
| Cost sharing | not required |
| Assistance Listings | 81.049 |

## Who can apply

- Others (see text field entitled "Additional Information on Eligibility" for clarification)

All types of domestic applicants are eligible to apply, except nonprofit organizations described in section 501(c)(4) of the Internal Revenue Code of 1986 that engaged in lobbying activities after December 31, 1995.Federally affiliated entities must adhere to the eligibility standards below:1. DOE/NNSA National LaboratoriesDOE/NNSA National Laboratories are not eligible to submit applications under this FOA but may be proposed as subrecipients under another organization’s application. If recommended for funding as a proposed subrecipient, the value of the proposed subaward will be removed from the prime applicant’s award and will be provided to the laboratory through the DOE Field-Work Proposal System and work will be conducted under the laboratory’s contract with DOE. No administrative provisions of this FOA will apply to the laboratory or any laboratory subcontractor. Additional instructions for securing authorization from the cognizant Contracting Officer are found in Section VIII of this FOA.2. Non-DOE/NNSA FFRDCsNon-DOE/NNSA FFRDCs are not eligible to submit applications under this FOA but may be proposed as subrecipients under another organization’s application. If recommended for funding as a proposed subrecipient, the value of the proposed subaward may be removed from the prime applicant’s award and may be provided through an interagency agreement to the FFRDC’s sponsoring Federal Agency. Additional instructions for securing authorization from the cognizant Contracting Officer are found in Section VIII of this FOA.3. Other Federal AgenciesOther Federal Agencies are not eligible to submit applications under this FOA but may be proposed as subrecipients under another organization’s application. If recommended for funding as a proposed subrecipient, the value of the proposed subaward may be removed from the prime applicant’s award and may be provided through an interagency agreement. Additional instructions for providing statutory authorization are found in Section VIII of this FOA.

## What the grant funds

Crop plants developed to be productive on lands unsuitable for traditional agricultural crops have the potential to play a significant role in the emerging bioeconomy as an alternative source of renewable feedstocks for fuels and chemicals. Plant scientists and breeders recognize that potentially bigger gains in productivity and sustainability may be realized in such crops by leveraging multi-omics approaches, systems biology, and computational biology to better understand the regulation of critical plant processes at the molecular level. However, understanding molecular function remains a challenge in plants due to several unique features, such as segmental and whole genome duplications, differences in mode of reproduction, and domestication. Advances in ‘omics technologies together with computational modeling and data analysis are enabling the gathering of information on critical and complex plant processes such as metabolism, development, and signaling. Although immense amounts of data can be generated by these methodologies, much of the functional information obtained from them is generated by correlation analysis and computational inference, lacking causal and verifiable knowledge. Experimental characterization of gene function continues to be a significant bottleneck, hampering our ability to fully exploit the potential of available ‘omics data. This in turn limits direct understanding of how genes regulate organismal function and ultimately the ability to accurately assign and validate gene function in non-model organisms. By elucidating complex regulatory processes at the molecular, cellular, and organismal levels, a better understanding of plants as a whole and a more accurate prediction of plant behavior under varying conditions can be achieved. To overcome these obstacles, more efficient, high-throughput methods for interpreting experimental evidence need to be developed for accurate determination of gene function. While experimental approaches are unlikely to scale with advances in ‘omics technologies, concentrated development and application of new approaches are required to tackle this critical knowledge gap of genomics space. The overarching goal of this FOA is to address the challenges and opportunities in associating gene(s) to function (i.e., genotype to phenotype) in plant systems of relevance to the BER mission in energy and the environment.

## Questions people ask

### Is DE-FOA-0002601 still open?

No. It closed on March 25, 2022. A newer notice is open: DE-FOA-0003673, closes January 12, 2027 (66 days left).

### Who can apply for Genomics-Enabled Plant Biology for Determination of Gene Function?

Office of Science accepted applications from the applicants described in the notice. The notice adds further conditions, so read its eligibility section.

### What is the deadline for Genomics-Enabled Plant Biology for Determination of Gene Function?

Closed March 25, 2022. Applications are no longer accepted; the program's newer notices are on this page when there are any.

### How much funding is available?

Awards of up to $1.0 million each. About $30.0 million in total.

### Who has won Office of Science Financial Assistance Program grants before?

The largest recipients over five fiscal years were Michigan State University Foundation, General Atomics, University of Wisconsin System. The program made 6,205 awards worth $7.7 billion in that time.