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Grants / Department of Health and Human Services / Centers for Disease Control - NCHHSTP

Controlling and Preventing STIs in US Health Departments (CAP-STIs)

Forecast Expected deadline January 11, 2027 Opportunity CDC-RFA-PS-27-0008

Centers for Disease Control - NCHHSTP plans to offer grants to state and local governments. It expects to make about 59 awards worth $500 million in total. It is a forecast: the notice is expected around November 10, 2026, with applications due around January 11, 2027.

From the official notice on Grants.gov, last changed September 2, 2026. Checked October 31, 2026.

Key dates

Forecast postedMay 11, 2026
Expected postingNovember 10, 2026
Expected deadlineJanuary 11, 2027
Expected award dateFebruary 1, 2027

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Who can apply

This opportunity is open to state and local governments.

All fifty (50) states, the District of Columbia, the US Virgin Islands and Puerto Rico are eligible to apply. To ensure implementation of STI control and prevention nationwide, CDC intends to fund all fifty states, the District of Columbia, the US Virgin Islands and Puerto Rico, non-competitively, according to a funding formula based on the respective jurisdiction"s population & morbidity of three reportable STIs (chlamydia, gonorrhea and primary & secondary syphilis).Section 318(c) of the Public Health Services Act, 42 USC 247c(c), provides that the Secretary of HHS may provide funding to "States and, in consultation with the State health authority, to political subdivisions of States..." to conduct STI prevention & control projects. This language allows CDC to fund cities in addition to their respective states. Under the previous STI prevention & control funding opportunity PS19-1901 (& prior to that, PS14-1402), CDC funded the following cities based upon population, STI morbidity & organizational capacity: New York City, Philadelphia, Baltimore, Chicago, Los Angeles & San Francisco. To maximize the efficiency of program delivery, CDC may again fund a limited number of cities under this award. Funding for cities will be awarded competitively, based on the same criteria shown above for the state formula: population, STI morbidity, as well as organizational capacity. Directly funded cities must have a demonstrated capacity to report chlamydia, gonorrhea and syphilis surveillance data to CDC; an agreement with their parent state to apply separately for NOFO funding & to coordinate/collaborate appropriately following any funding; & data showing that the surrounding metropolitan statistical area (MSA) reported 2024 data showing:> or = to 500 cases of syphilis aged 15-44 reported in 2024 > or = 7500 cases of gonorrhea aged 15-44 reported in 2024 > or = to 15,000 cases of chlamydia aged 15-44 reported in 2024 > or = to 4 million residents estimated in 2024 Cities that apply for funding must submit their 2024 surveillance summary demonstrating the number of required cases & residents, a joint statement of collaboration/coordination with their respective state, or a letter indicating the city has notified the state of its application for funding of this award. In the event that cities do not compete successfully for the funding, all funds will be provided to the state, which will be responsible for distributing funds to its constituent cities as appropriate.

More grants for state and local governments.

Is this a realistic fit?

What the grant funds

CDC is funding programs that track, prevent, and control sexually transmitted infections (STI) in state, district, territorial, and city or county health departments. The purpose of this NOFO is to track, prevent, and control three common STIs: syphilis, gonorrhea, and chlamydia. The NOFO supports the goals of the Sexually Transmitted Infections National Strategic Plan 2021-2025: Prevent new STIs. Improve the health of people by reducing adverse outcomes of STIs. Implement STI prevention technology and innovations more quickly. Reduce the impact of STIs in areas or populations disproportionately impacted by STIs. Achieve integrated, coordinated efforts that address the STI epidemic. Local surveillance data will determine the priority populations for this NOFO. Each program should focus on populations that are disproportionately impacted by STI transmission. To be successful with this NOFO, you will need to collaborate with partners to address interconnected comorbidities and sexual health.

Category: Health.

How to apply

  1. Read the full notice and attachments on Grants.gov. The notice is the official source for deadlines and requirements.
  2. Make sure your organization has an active SAM.gov registration and Unique Entity ID; registration can take several weeks.
  3. Register on Grants.gov and submit through Workspace before the deadline and time given in the notice. Our application guide walks through each step.

Questions go to Mary McFarland, xzm3@cdc.gov, 404.639.8309.

Open the official notice

Questions people ask

Who can apply for Controlling and Preventing STIs in US Health Departments (CAP-STIs)?

Centers for Disease Control - NCHHSTP accepts applications from state and local governments. The notice adds further conditions, so read its eligibility section.

What is the deadline for Controlling and Preventing STIs in US Health Departments (CAP-STIs)?

Expected deadline January 11, 2027. Confirm the date and time in the official notice on Grants.gov.

How much funding is available?

About $500 million in total across about 59 awards.

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